Canada residents can call a provincial poison control center. PDF Venofer Guidelines for Use 2011 - University Health System Applies only to oral form of both agents. To provide clinicians with evidence-based guidance for iron therapy dosing in patients with iron deficiency anemia (IDA), we conducted a study examining the benefits of a higher cumulative dose of intravenous (IV) iron than what is typically administered. commonly, these are "non-preferred" brand drugs or specialty 2.1 . Minor/Significance Unknown. iron sucrose decreases levels of ciprofloxacin by inhibition of GI absorption. Applies only to oral form of both agents. Monitor Closely (1)ibuprofen/famotidine will decrease the level or effect of iron sucrose by increasing gastric pH. A patients lean body weight (or actual body weight if less than lean body weight) should be utilized when determining dosage. The dosage is expressed in terms of mg of elemental iron, with each mL of Feraheme containing 30 mg of elemental iron. trientine, iron sucrose. Multivalent cation-containing products may impair absorption of tetracyclines, which may decrease its efficacy. Prescribing and dispensing information For iron sucrose A complex of ferric hydroxide with sucrose containing 2% (20 mg/mL) of iron. A maximum dose of 1000 mg iron can be delivered intravenously over 15 minutes, which may make it a suitable treatment for iron-deficiency anaemia outside of the hospital setting. Administer on 5 different occasions over a 14 day period. Case G. Maintaining iron balance with total-dose infusion of intravenous iron dextran. . Do not dilute to concentrations below 1 mg/mL [see How Supplied/Storage and Handling (16.2).] Applies only to oral form of both agents. Philadelphia, PA: Lippincott Williams & Wilkins;2013;303-307. Use Caution/Monitor. Iron Deficit - Multi-Calc - GlobalRPH - Medical Calculators, Clinicians Applies only to oral form of both agents. Applies only to oral form of both agents. Interaction only with oral iron administration. The dosing for iron replacement treatment in pediatric patients with NDD-CKD or PDD-CKD has not been established. Either increases effects of the other by pharmacodynamic synergism. Venofer is indicated for the treatment of iron deficiency anemia (IDA) in patients with chronic kidney disease (CKD). Avoid or Use Alternate Drug. Foods rich in iron include meats (especially liver), eggs, raisins, figs, broccoli, brussels sprouts, beans, lentils, and iron-fortified or enriched cereals. 1. Minor/Significance Unknown. calcium acetate decreases levels of iron sucrose by inhibition of GI absorption. Monitor Closely (1)trientine, iron sucrose. Administer Venofer 100 mg undiluted as a slow intravenous injection over 2 to 5 minutes, or as an infusion of 100 mg diluted in a maximum of 100 mL of 0.9% NaCl over a period of at least 15 minutes, per consecutive hemodialysis session. Applies only to oral form of both agents. Transferrin saturation (TSAT) values increase rapidly after intravenous administration of iron sucrose; do not perform serum iron measurements for at least 48 hours after intravenous dosing. The recommended dosage of iron sucrose for repletion of iron deficiency in patients undergoing hemodialysis is 5ml of iron sucrose (100mg of elemental iron) delivered intravenously during the dialysis session. The usual total treatment course of Venofer is 1000 mg. Venofer treatment may be repeated if iron deficiency reoccurs. Results: Twelve children (6 females) aged 1.2-14 years (median age 8.9 years) received at least one dose of . Serious - Use Alternative (1)iron sucrose decreases levels of ofloxacin by inhibition of GI absorption. Observed Hb = the patients current hemoglobin in g/dl. Anemia of chronic disease (ACD), Calculation of the Total Iron Deficit equation appears in Cosmofer PI, Iron Dextran Dosing Calculator (iron deficit). Minor/Significance Unknown.iron sucrose increases levels of calcium citrate by enhancing GI absorption. We'll do this entirely for free, as long as the calculator has applications for women's health. Applies only to oral form of both agents. Treatment of iron deficiency anemia in adults - UpToDate Modify Therapy/Monitor Closely. Applies only to oral form of both agents. Applies only to oral form of both agents. Monitor Closely (1)lansoprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Applies only to oral form of both agents. Monitor Closely (1)iron sucrose decreases levels of liothyronine by inhibition of GI absorption. This may be helped by giving the medication more slowly or at a lower dose. Applies only to oral form of both agents. Max Dose. This health tool computes the required parenteral iron replacement dose for the iron deficit extracted from the patient weight and hemoglobin level from complete blood count test. Your body may also need more iron if you use the drug erythropoietin to help make new red blood cells.Iron is an important part of your red blood cells and is needed to transport oxygen in the body. Venofer® (iron sucrose) injection, USP is indicated for the treatment of iron deficiency anemia (IDA) in patients with chronic kidney disease (CKD). Parenteral Iron Replacement For Iron Deficiency Anemia Calculator Iron sucrose (Venofer) 100 mg/5 mL vial 200 - 300 mg given every 3-7 days 300 mg doses are given over 90 minutes 500 mg/dose. Situation Analysis Market Size MAT Sales Cr LC MAT Share % MAT Gr % Total Pharma Market 9388.69 100 13.5 Iron Sucrose 11.18 93.81 37.65 Brand Company Saline MAT . IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. 300-500 mg Iron Sucrose in NS 250 mL administered over three (3) hours; may repeat as needed in 3-7 days to reach 1 gm. cimetidine will decrease the level or effect of iron sucrose by increasing gastric pH. Sodium ferric gluconate (Ferrlecit) 62.5 mg . Serum iron, total iron binding capacity (TIBC) and percent saturation of transferrin are other important tests for detecting and monitoring the iron deficient state. Each mL contains 20 mg of elemental iron. Serious - Use Alternative (1)iron sucrose decreases levels of doxycycline by inhibition of GI absorption. Mean change in Hgb from baseline to Week 5 2,5 Your doctor will do laboratory tests to monitor your response. Intravenous iron-dextran: therapeutic and experimental possibilities. A: Generally acceptable. Administer Venofer in 3 divided doses, given by slow intravenous infusion, within a 28 day period: 2 infusions each of 300 mg over 1.5 hours 14 days apart followed by one 400 mg infusion over 2.5 hours 14 days later. J Lab Clin Med. Iron metabolism needs to be balanced and bleeding, the major cause of iron deficiency (for instance in menstruation in females and chronic occult gastrointestinal bleeding) needs to be addressed. Iron sucrose | Drugs | BNF | NICE Administer Feraheme as an intravenous infusion in 50-200 mL 0.9% Sodium Chloride Injection, USP or 5% Dextrose Injection, USP over at least 15 minutes. Separate by at least 4 hours. 1998 Feb;25(1):65-8. In key trials, ferric carboxymaltose increased Hb levels and replenished iron stores as effectively as IV iron sucrose . * Calculators are available in UpToDate to determine ideal body weight and lean body weight. Schweiz Med Wochenschr; 100(7):301-3. * Adapted from the KDIGO Clinical Practice Guideline for Anemia in Chronic Kidney Disease. Use Caution/Monitor. Use Caution/Monitor. *Administer early during the dialysis session. Intravenous iron sucrose: establishing a safe dose - PubMed iron sucrose decreases levels of levofloxacin by inhibition of GI absorption. Avoid or Use Alternate Drug. Administer Venofer early during the dialysis session (generally within the first hour). (2010) Diagnosis and management of iron deficiency anaemia: a clinical update. Adding plans allows you to compare formulary status to other drugs in the same class. Applies only to oral form of both agents. During all INFeD administrations, observe for signs or symptoms of anaphylactic-type reactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Monitor Closely (1)iron sucrose decreases levels of deferiprone by enhancing GI absorption. Nutrition. Do not administer Venofer to patients with evidence of iron overload. Copyright 2021 GlobalRPH - Web Development by, Calculation of the Total Iron Deficit Alternative equation. Applies only to oral form of both agents. Schweiz Med Wochenschr. Tell your caregivers if you feel any burning, pain, or swelling around the IV needle when Venofer is injected. Applies only to oral form of both agents. ANNA J. Where C is the concentration of the iron product: Please note that the calculations above are for information purposes only and the individual dose needs to be established by taking into account the current package insert for the elemental iron product used. commonly, these are "non-preferred" brand drugs. DICP. an automated flowchart approach. It varies from increases in dietary intake of iron (usually for prophylaxis purposes) to oral, intramuscular or intravenous therapy. This website is intended for use by US healthcare professionals only. Privacy Policy, Use 500 mg for adults and children 35 kg; use 15 mg/kg if <35 kg. A patients lean body weight (or actual body weight if less than lean body weight) should be utilized when determining dosage. FERAHEME was non-inferior to Venofer (iron sucrose) in mean Hgb rise from baseline 2,5. Avoid or Use Alternate Drug. By using this form you agree with the storage and handling of your data by this website. Nutr Clin Pract. Modify Therapy/Monitor Closely. Applies only to oral form of both agents. 4)Pasricha SR, Flecknoe-Brown SC, Allen KJ, Gibson PR, McMahon LP, Olynyk JK, Roger SD, Savoia HF, Tampi R, Thomson AR, Wood EM, Robinson KL. Congenital Pulmonary Airway Malformation Volume Ratio (CVR) Calculator -. There is no resource limitation, as if the tool was hosted on your site, so all your users can make use of it 24/7; The necessary tool updates will take place in real time with no effort on your end; A single click install to embed it into your pages, whenever you need to use it. Administer on 5 different occasions over a 14 day period. Applies only to oral form of both agents. Baloxavir may bind to polyvalent cations resulting in decreased absorption. PRECAUTIONS: Before using iron sucrose, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This cost includes the fee charged by the pharmacy. Last updated on Jun 1, 2022. Multivalent cation-containing products may impair absorption of tetracyclines, which may decrease its efficacy. Use Caution/Monitor. Multiple placebo-controlled, randomized clinical trials have been conducted with IV iron in patients with New York Heart Association class II-III heart failure with an ejection fraction 45% who met criteria . Applies only to oral form of both agents. Discuss the risks and benefits with your doctor.This medication passes into breast milk. Venofer (iron sucrose injection, USP) For Intravenous Use Only INDICATION AND USAGE Venofer (iron sucrose injection, USP) is indicated for the treatment of iron deficiency anemia (IDA) in patients with chronic kidney disease (CKD). Hypotension following administration of Venofer may be related to rate of administration and/or total dose delivered. For males: LBW = 50 kg + 2.3 kg for each inch of patients height over 5 feet For females: LBW = 45.5 kg + 2.3 kg for each inch of patients height over 5 feet. Anemia; 2015: 763576. vitamin E decreases levels of iron sucrose by increasing hepatic clearance. Venofer treatment may be repeated if necessary. Avoid or Use Alternate Drug. Anemia of chronic disease (ACD), Calculation of the Total Iron Deficit equation appears in Cosmofer PI, Calculation of the Total Iron Deficit Alternative equation, Iron Dextran Dosing Calculator (iron deficit), HONcode standard for trust- worthy health, Pediatric Oncology: Diagnosis And Prognosis Communication, Pharmacosmos A/S, CosmoFer low molecular weight (Mw) iron dextran. Step 2: Calculation and administration of the maximum individual iron dose(s): . Serious - Use Alternative (1)iron sucrose decreases levels of tetracycline by inhibition of GI absorption. Avoid or Use Alternate Drug. Applies only to oral form of both agents. Share cases and questions with Physicians on Medscape consult. These are real scientific discoveries about the nature of the human body, which can be invaluable to physicians taking care of patients. Applies only to oral form of both agents. Assessing new treatment options. Hollands J, Foote E, Rodriguez A. 1 ,*. On the other hand, slow decreases, such as that in chronic occult gastrointestinal bleeding are often difficult to diagnose. Parenteral Iron Replacement For Anemia Calculator - MDApp By clicking send, you acknowledge that you have permission to email the recipient with this information. Applies only to oral form of both agents. iron sucrose increases levels of calcium citrate by enhancing GI absorption. 4) Gozzard D. (2011) When is high-dose intravenous iron repletion needed? In the text below the tool there is more information on how the iron deficit is calculated. The primary endpoint was the proportion of patients with . Use Caution/Monitor. Applies only to oral form of both agents. Calculates iron deficit for dosing iron. 1988 May;111(5):566-70. The two formulas used are presented below: Iron deficit in mg = Weight in kg x (14 - Hb in g/dL) x 2.145 Volume of product required in mL = Iron deficit in mg / C in mg/mL Where C is the concentration of the iron product: 50 mg/mL for Iron dextran; 20 mg/mL for Iron sucrose; 5 mg/mL for Ferric gluconate. Minor/Significance Unknown. https://www.uptodate.com/ (Requires subscription). iron sucrose decreases levels of gemifloxacin by inhibition of GI absorption. When administered via infusion, dilute up to 750 mg of iron in no more than 250 mL of sterile 0.9% sodium chloride injection, USP, such that the concentration of the infusion is not less than 2 mg of iron per mL and administer over at least 15 minutes. . Generic name: IRON SUCROSE 20mg in 1mL Minor/Significance Unknown. Dose. Minor/Significance Unknown. Minor/Significance Unknown. One dose IV Iron replacement | Monoferric VENOFER (IRON SUCROSE INJECTION,USP) 100mg ELEMENTAL IRON - DailyMed Formula for calculating the required dose of iron sucrose Either increases effects of the other by pharmacodynamic synergism. This topic . Avoid or Use Alternate Drug. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Avoid or Use Alternate Drug. This site complies with the HONcode standard for trust- worthy health information: verify here. Applies only to oral form of both agents. The Ganzoni equation used by the iron deficiency calculator is the following: Total iron deficit (mg) = Weight in kg x (Target Hb - Actual Hb in g/dL) x 2.4 + Iron stores The recommendation is that most adults need a cumulative dose of elemental iron of at least 1 g. Pasricha SR, Flecknoe-Brown SC, Allen KJ, Gibson PR, McMahon LP, Olynyk JK, Roger SD, Savoia HF, Tampi R, Thomson AR, Wood EM, Robinson KL. Please confirm that you would like to log out of Medscape. . It is unlikely . Dosage Calculator Do Not Copy, Distribute or otherwise Disseminate without express permission. DOSAGE AND ADMINISTRATION: The recommended dose of Feraheme is an initial 510 mg dose followed by a second 510 mg dose 3 to 8 days later. Available for Android and iOS devices. Test Dose: Not required. Indications: Feraheme is indicated for the treatment of iron deficiency anemia (IDA) in adult patients: who have intolerance to oral iron or have had unsatisfactory response to oral iron or who have chronic kidney disease (CKD). In: Koda-Kimble & Young's Applied Therapeutics: The Clinical Use of Drugs. Ferumoxytol [ Feraheme ] Elemental iron: 510 mg/17 mL (17 mL) 30 mg/mL [package insert] - Boxed warning REVIEW INSERT. Avoid or Use Alternate Drug. Minor (2)calcium chloride decreases levels of iron sucrose by inhibition of GI absorption. In most cases, adult patients require a cumulative dose of elemental iron of at least 1 g. Most commonly, iron replenishment therapy is done intravenously: As total dose (iron-dextran or iron carboxymaltose); Iron deficiency is common during childhood growth, prolonged periods of sickness, in convalescence or during pregnancy. May increase risk of hypotension. Individual doses of 2 mL or less may be given on a daily basis until the calculated total amount required has been reached. WARNING: RISK FOR SERIOUS HYPERSENSITIVITY/ANAPHYLAXIS REACTIONS Fatal and serious hypersensitivity reactions including anaphylaxis have occurred in patients receiving Feraheme. Applies only to oral form of both agents. Below the form there are further instructions on how to use the calculator. Use Caution/Monitor. Either decreases levels of the other by inhibition of GI absorption. Maintain a well-balanced diet, and follow any dietary guidelines as directed by your doctor. PDF Treatment Guideline - Gloucestershire Royal Hospital 1 Dosing for patients who weigh less than 50 kg iron sucrose decreases levels of fleroxacin by inhibition of GI absorption. ADMINISTER THE TEST DOSE AT A GRADUAL RATE OVER AT LEAST 30 SECONDS. PDF Venofer - Food and Drug Administration Iron Sucrose - SlideShare It is usually given slowly over 2 to 5 minutes or as directed by your doctor. This document does not contain all possible drug interactions. Monitor Closely (1)iron sucrose decreases levels of ibandronate by inhibition of GI absorption. The dosage of iron sucrose is expressed in mg of elemental iron. The dose of Ferinject is based on calculation of ideal body weight and calculation of iron deficit using the Ganzoni formula. (1970) Intravenous iron-dextran: therapeutic and experimental possibilities. Copyright 1993-2021 Patients diagnosed with iron deficiency are prescribed iron supplementation, either to replete body stores or to correct anemia. Intravenous therapy is usually recommended in case of contraindications to oral iron, comorbidities that prevent absorption, chronic renal impairment or iron replacement needs to be rapid. This website also contains material copyrighted by 3rd parties. Applies only to oral form of both agents. There are three fields in the parenteral iron replacement for iron deficiency anemia calculator: Weight can be input in either lbs or kilograms and the required transformations are performed by the calculator. The cost of Venofer is $145 for a dose of 300 mg and Monoferric is $274 for a dose of 500mg. Avoid or Use Alternate Drug. Dose administration to an elderly patient should be cautious, reflecting the greater frequency of decreased hepatic, renal or cardiac function, and of concomitant disease or other drug therapy. Hemoglobin iron deficit = 60 x (14 - 8) x (2.145) = 772 mg iron. For iron maintenance treatment: Administer Venofer at a dose of 0.5 mg/kg, not to exceed 100 mg per dose, every four weeks for 12 weeks given undiluted by slow intravenous injection over 5 minutes or diluted in 0.9% NaCl at a concentration of 1 to 2 mg/mL and administered over 5 to 60 minutes. Monitor Closely (1)deferoxamine decreases levels of iron sucrose by inhibition of GI absorption. Aranesp (darbepoetin alfa) | Dosing Considerations It is usually given slowly over 2 to 5 minutes or as directed by your doctor. Venofer (iron sucrose) 20 mg iron / ml, solution for injection or Applies only to oral form of both agents. 1982;13(4):309-21. Koch TA, Myers J, Goodnough LT. Intravenous Iron Therapy in Patients with Iron Deficiency Anemia: Dosing Considerations. Option 2: 200 mg in NS 100 mL administered over 20-30 minutes; may repeat every other day to No data are available regarding overdosage of Venofer in humans. View the formulary and any restrictions for each plan. iron sucrose decreases levels of ofloxacin by inhibition of GI absorption. Use Caution/Monitor. Mean Corpuscular Hemoglobin Concentration (MCHC) Calculator, Red Blood Cell (RBC) Indices Calculator, Iron Deficiency In Pregnancy Calculator. Applies only to oral form of both agents. Next Steps Evidence Creator Insights Dr. Andreas M. Ganzoni About the Creator Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Applies only to oral form of both agents. Avoid or Use Alternate Drug. Pediatric Patients: The most common adverse reactions (2%) are headache, respiratory tract viral infection, peritonitis, vomiting, pyrexia, dizziness, cough, nausea, arteriovenous fistula thrombosis, hypotension and hypertension. There is limited experience with administration of an infusion of 500 mg of Venofer, diluted in a maximum of 250 mL of 0.9% NaCl, over a period of 3.5 to 4 hours on Day 1 and Day 14. deferoxamine decreases levels of iron sucrose by inhibition of GI absorption. Can't find what you need? The recipient will receive more details and instructions to access this offer. In case a pediatric patient with a weight below 35 kg is assessed, iron stores are calculated as 15 mg iron for each kg. The factor 2.4 is derived from the following assumptions: a) Blood volume 70 ml/kg of body weight ~7% of body weight b) Iron content of hemoglobin 0.34% Factor 2.4 = 0.0034 x 0.07 x 10000 (conversion for g/dL) Ganzoni AM. sodium citrate/citric acid will decrease the level or effect of iron sucrose by increasing gastric pH.
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